A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis
NCT06900192 · Status: NOT_YET_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2025-03-28
Summary
A study of alloHCT with Orca-Q for the treatment of primary progressive multiple sclerosis (MS).
Conditions
- Primary Progressive Multiple Sclerosis
- Multiple Sclerosis
- Multiple Sclerosis, Primary Progressive
- Multiple Sclerosis, Secondary Progressive
Interventions
- BIOLOGICAL
-
Orca-Q
Allogeneic (donor) stem cell graft
- DRUG
-
myeloablative regimen
Myeloablative regimen of busulfan, fludarabine, and thiotepa.
Sponsors & Collaborators
-
Orca Biosystems, Inc.
collaborator INDUSTRY - lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-03-31
- Primary Completion
- 2029-08-31
- Completion
- 2029-08-31
- FDA Drug
- Yes
More Related Trials
-
Observational Study in Multiple Sclerosis Patients Treated With Autologous Hematopoietic Stem Cell Transplantation
NCT04674280 ·Status: UNKNOWN
-
Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)
NCT02688985 ·Status: COMPLETED ·Phase: PHASE3
-
Immunological Mechanisms of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis
NCT00342134 ·Status: COMPLETED ·Phase: PHASE2
-
RRMS: Disease PROgression and Myeloid Profiling After Bone Marrow TRANSPLANTation and Second Line Therapies
NCT06267781 ·Status: RECRUITING
-
Mesenchymal Stem Cells for the Treatment of MS
NCT00781872 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Mesenchymal Stem Cell Transplantation in MS
NCT01228266 ·Status: TERMINATED ·Phase: PHASE2
-
Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis
NCT06228781 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Phase I-II Clinical Trial With Autologous Bone Marrow Derived Mesenchymal Stem Cells for the Therapy of Multiple Sclerosis
NCT02035514 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Feasibility Study of Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in Patients With Multiple Sclerosis
NCT02034188 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple Sclerosis
NCT06677710 ·Status: SUSPENDED ·Phase: PHASE1
-
Safety and Efficacy Study of Autologus Bone Marrow Mesenchymal Stem Cells in Multiple Sclerosis
NCT01895439 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis
NCT04943289 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Efficacy of Autologous Mesenchymal Bone Marrow Stem Cells in Active & Progressive Multiple Sclerosis
NCT02166021 ·Status: COMPLETED ·Phase: PHASE2
-
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for MS
NCT05003388 ·Status: RECRUITING ·Phase: PHASE1
-
Multi-Center Study Safety of Adipose Derived Mesenchymal Stem Cells for the Treatment of Multiple Sclerosis
NCT02326935 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis
NCT06138132 ·Status: RECRUITING ·Phase: PHASE1
-
Expanded Access to Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis
NCT03822858 ·Status: AVAILABLE
-
An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment
NCT06675955 ·Status: RECRUITING ·Phase: PHASE3
-
Autologous Mesenchymal Stromal Cells for Multiple Sclerosis
NCT02495766 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Phase I Study of High-Dose Cyclophosphamide and Total Body Irradiation With T Lymphocyte-Depleted Autologous Peripheral Blood Stem Cell or Bone Marrow Rescue in Patients With Multiple Sclerosis
NCT00017628 ·Status: COMPLETED ·Phase: PHASE1
-
The Effects of Erythropoietin on Clinical Disability and Brain Pathology in Patients With Progressive Multiple Sclerosis
NCT01144117 ·Status: UNKNOWN ·Phase: PHASE2
-
Study to Investigate the Safety of the Transplantation of Human Glial Restricted Progenitor Cells Into Subjects With Transverse Myelitis
NCT03887273 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Patients With Multiple Sclerosis
NCT01933802 ·Status: COMPLETED ·Phase: PHASE1
-
Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis
NCT03355365 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Mesenchymal Autologous Stem Cells as Regenerative Treatment for Multiple Sclerosis
NCT04749667 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2