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Pulmonary Deposition of Ultrasound Rock Salt Aerosol Inhalation Therapy

NCT06891274 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2025-03-24

No results posted yet for this study

Summary

In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model. By combining 3D printing experiments with CFD simulations, the investigators will investigate the respiratory tract deposition rate and distribution of micro - moist particles in ultrasound rock salt aerosol inhalation therapy. This will be compared with a small - volume nebulizer to verify the effectiveness of ultrasound rock salt aerosol inhalation therapy and lay the foundation for further research on the application of this inhalation technique to other drug formulations.

In the clinical phase, the investigators plan to have subjects inhale radioactive aerosols and use PET/CT imaging technology to assess the deposition rate of aerosol particles in the lungs. By quantitatively analyzing the images, the investigators will study their distribution characteristics in real human bodies to verify the accuracy of the in vitro models and the potential for clinical application.

Conditions

  • COPD
  • Asthma Bronchiale
  • Chronic Bronchitis

Interventions

DEVICE

USN before SVN

The group that received ultrasonic rock salt aerosol inhalation therapy followed by small-volume nebulized inhalation therapy.

DEVICE

SVN before USN

The group that received small-volume nebulized inhalation therapy followed by ultrasonic rock salt aerosol inhalation therapy.

Sponsors & Collaborators

  • Jingen Xia

    lead OTHER

Principal Investigators

  • Jingen Xia, M.D · China-Japan Friendship Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-31
Primary Completion
2026-01-31
Completion
2026-03-31

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06891274 on ClinicalTrials.gov