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Single vs Hypofractionated Irradiation For Timely Access to Partial Breast Radiotherapy

NCT06885671 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-11-17

No results posted yet for this study

Summary

Partial Breast Irradiation (PBI) is a targeted radiation approach commonly administered post-lumpectomy, specifically targeting the tumour bed. This targeted therapy reduces the exposure to other nearby tissues such as lungs, heart, and chest wall. However, traditional PBI treatment involves lengthy multiple fraction courses which presents a burden to patients from rural and remote communities, who must travel long distances to receive high quality cancer care. The purpose of this study is to compare single fraction (SF) PBI vs. multiple fraction (MF) PBI.

Conditions

  • Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Interventions

RADIATION

Multiple Fraction PBI

Participants randomized to Arm 1 will receive PBI with a dose of 26 Gy in 5 daily fractions.

RADIATION

Single Fraction PBI

Participants randomized to Arm 2 will receive PBI in a single fraction with a dose of 13 Gy.

Sponsors & Collaborators

  • British Columbia Cancer Agency

    lead OTHER

Principal Investigators

  • Robert Olson, MD, MSc, FRCPC · BC Cancer - Prince George

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-31
Primary Completion
2029-12-31
Completion
2029-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06885671 on ClinicalTrials.gov