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Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application

NCT06883214 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2025-03-19

No results posted yet for this study

Summary

Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopic expression of the miRNAs identified by us has a negative impact on cell viability, proliferation and apoptosis, but above all on migration and invasion.

Conditions

Sponsors & Collaborators

  • University of Roma La Sapienza

    collaborator OTHER

  • San Camillo Hospital, Rome

    collaborator OTHER

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    collaborator OTHER

  • Neuromed IRCCS

    collaborator OTHER

  • Regina Elena Cancer Institute

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-17
Primary Completion
2027-01-17
Completion
2027-01-17

Countries

  • Italy

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06883214 on ClinicalTrials.gov