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Reducing Pain With Methadone and Ketamine in Liver Transplant

NCT06868589 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-04-07

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery.

The main questions it aims to answer are:

* What impact does using methadone and ketamine during a deceased donor liver transplant have on pain after surgery?
* Does the use of methadone and ketamine also have an impact on mental confusion (delirium) after surgery?

Researchers will compare the use of methadone and ketamine to standard of care to see if the two drugs work to decrease pain and impact delirium after liver transplant.

Participants will:

* Receive either methadone and ketamine or standard of care during their deceased donor liver transplant.
* Allow researchers to follow medical care throughout inpatient stay.

Conditions

  • Liver Transplantation

Interventions

DRUG

Methadone

Participants in this group will receive one bolus dose of intravenous Methadone and Ketamine at the start of operation

DRUG

ketamine

Participants in this group will receive one bolus dose of intravenous Methadone and Ketamine at the start of operation

DRUG

Hydromorphone

Participants in this group will receive standard of care for pain with either intravenous fentanyl and/or hydromorphone boluses during the procedure

DRUG

fentanyl

Participants in this group will receive standard of care for pain with either intravenous fentanyl and/or hydromorphone boluses during the procedure

Sponsors & Collaborators

  • Lahey Clinic

    lead OTHER

Principal Investigators

  • Ryan Nazemian, MD, PhD · Lahey Hospital and Medical Center, Department of Anesthesiology, Perioperative and Pain Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-30
Primary Completion
2026-07-01
Completion
2026-09-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06868589 on ClinicalTrials.gov