Nordic Consortium for Acute Type a Aortic Dissection-2

Summary

The Nordic Consortium for Acute Type A Aortic Dissection-2 (NORCAAD-2) is a multicenter research collaboration involving up to 19 units in the Nordic countries and one in The Netherlands. All patients referred for this condition is included, to outline detailed preoperative characteristics and risk factors as well as, for those operated, data on the operative procedure, the postoperative course including major and minor complications and, as the primary interest, mortality in short- and long-term perspective. The need for further procedures on the aorta will also be studied.

Acute type A Aortic Dissection (ATAAD) is a vascular emergency with very high case-fatality rate. The condition is realtively infrequent, and single units can rarely amass sufficient number of patients during a reasonable time to analyse also unusual variants in background, presentation, and management. Randomized controlled trials are unlikely, and large multicenter databases are the best source of knowledge for the foreseeable future. Other such databases exist, but NORCAAD-2 is more focused (only ATAAD) and more detailed than many counterparts, with the ability to extract unique information.

NORCAAD-2 is the extension and expansion of the original NORCAAD project. NORCAAD-2 includes more centers, more patients, more data and utilizes a novel on-line common database designed for the purpose.

The ultimate goal is to identify novel risk markers to help inform decisions on pre-emptive surgery (before ATAAD occurs); to outline superior perioperative techniques and strategies to optimize outcomes both short- and long-term; and to analyze variables related to major complications, in an effort to further reduce their incidence.

Conditions

• Aortic Dissection

Interventions

PROCEDURE

surgery

Open heart surgery

PROCEDURE

endovascular intervention

Aortic endovascular intervention

Sponsors & Collaborators

• Aarhus University Hospital Skejby

  collaborator OTHER

• Haukeland University Hospital

  collaborator OTHER

• Rigshospitalet, Denmark

  collaborator OTHER

• Helsinki University Central Hospital

  collaborator OTHER

• Kuopio University Hospital

  collaborator OTHER

• Leiden University Medical Center

  collaborator OTHER

• Skane University Hospital

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Oslo University Hospital

  collaborator OTHER

• Landspitali University Hospital

  collaborator OTHER

• Norrlands University Hospital

  collaborator OTHER

• Tampere University Hospital

  collaborator OTHER

• Turku University Hospital

  collaborator OTHER_GOV

• Trondheim University Hospital

  collaborator OTHER

• University Hospital, Linkoeping

  collaborator OTHER

• Vastra Gotaland Region

  collaborator OTHER_GOV

• Uppsala University Hospital

  collaborator OTHER

• Blekinge County Council Hospital

  collaborator OTHER

• Örebro University, Sweden

  collaborator OTHER

• Karolinska Institutet

  lead OTHER

Principal Investigators

• Christian Olsson, MD, PhD · Karolinska Institutet

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-06-03

Primary Completion

2029-06-30

Completion

2030-06-30

Countries

• Sweden

Study Locations