Immediate Management of the Patient With Rupture : Open Versus Endovascular Repair

Summary

The purpose of this trial is to assess whether a strategy of endovascular repair (if aortic morphology is suitable, open repair if not) versus open repair reduces early mortality for patients with suspected ruptured abdominal aortic aneurysm (AAA).

Conditions

• Abdominal Aortic Aneurysm

Interventions

PROCEDURE

Open repair

Standard treatment of emergency open surgery

PROCEDURE

EVAR

Emergency endovascular aneurysm repair

Sponsors & Collaborators

• London School of Hygiene and Tropical Medicine

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• The Leeds Teaching Hospitals NHS Trust

  collaborator OTHER

• St George's, University of London

  collaborator OTHER

• Imperial College London

  lead OTHER

Principal Investigators

• Ray J. Ashleigh · Manchester University NHS Foundation Trust

• Simon J. Howell, MRCP(UK) MSc MD · Leeds Teaching Hospitals NHS Trust

• Ian Chetter, FRCS · Hull & East Yorkshire Hospitals NHS Trust

• Shane MacSweeney, MA MB BChir MChir FRCSEng · Nottingham University Hospitals NHS Trust

• Matthew J. Bown, MBChB MD FRCS (Gen Surg) · University Hospitals, Leicester

• Jonathan R Boyle, FRCSEd MD FRCS(Gen) · Cambridge Vascular Unit, Addenbrooke's Hospital

• Meryl Davis, FRCS · Royal Free Hampstead NHS Trust

• Matthew Thompson, FRCS · St George's Healthcare NHS Trust

• Colin D Bicknell, FRCS · Imperial College NHS Trust

• Dynesh Rittoo, MBChB FRCS · The Royal Bournemouth & Christchurch Hospitals NHS Foundation Trust

• Jonathan Davies, FRCS FRCS(Ed) · Royal Cornwall Hospitals NHS Trust

• Rachel Bell, FRCS · Guy's & St Thomas' Hospital

• Mike G Wyatt, FRCS · The Newcastle upon Tyne Hospitals NHS Trust

• Ferdinand Serracino-Inglott, FRCSI, FRCS · Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust

• Paul Bachoo, MBChB FRCS MSc · Aberdeen Royal Infirmary

• Woolagasen Pillay, FCS(SA) · Doncaster Royal Infirmary

• Syed W Yusuf, FRCS · Royal Sussex County Hospital

• Paul Walker · The James Cook University Hospital , South Tees Hospitals NHS Foundation Trust

• Colin Nice · Queen Elizabeth Hospital, Gateshead Health NHS Foundation Trust

• Andrew Gordon, FRCS · Cardiff and Vale University Health Board

• Adam Howard, FRCS · Colchester General Hospital

• Noel Wilson, FRCS MS · Kent and Canterbury Hospital

• Domenico Valenti, PhD FRCS FEBVS · King's College Hospital NHS Trust

• David McLain, MBBS, FRCS (Gen Surg), FEBVS · Aneurin Bevan Health Board

• Patrick Chong, FRCS · Frimley Park Hospital NHS Foundation Trust

• Raj Bhat,,FRCS(Ed),FRCR · NHS Tayside

• Luc Dubois, MSc · London Health Sciences Centre, University of Western Ontario, Canada

• Simon Hobbs, MD, FRCS (Eng), BMedSc · The Royal Wolverhampton Hospitals NHS Trust

• Stephen Cavanagh, MBChB, MD, FRCS(Gen) · York Teaching Hospital NHS Foundation Trust

• Timothy Rowlands, FRCS (Eng) · University Hospitals of Derby and Burton NHS Foundation Trust

• John Asquith, MRCP, FRCR · University Hospital of North Staffordshire

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

50 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-09-30

Primary Completion

2013-08-21

Completion

2016-07-21

Countries

• Canada
• United Kingdom

Study Locations