PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis

Summary

This is a prospective, observational cohort study. Participants with non-idiopatic pulmonary fibrosis, interstitial lung disease (ILD) will be followed for 24 months to systematically collect clinical, imaging, and biospecimen data. The primary objective is to optimize progressive pulmonary fibrosis (PPF) classification and establish PPF incidence for key ILD subtypes. Additional exploratory objectives are to 1) Prospectively validate a novel PPF classifier and assess performance durability over time, and 2) Determine whether multi-dimensional PPF prediction outperforms component approaches.

Conditions

• Progressive Pulmonary Fibrosis
• Interstitial Lung Disease

Sponsors & Collaborators

• University of Michigan

  collaborator OTHER

• University of Virginia

  collaborator OTHER

• Johannes Gutenberg University Mainz

  collaborator OTHER

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS

  collaborator OTHER

• University of Massachusetts, Worcester

  lead OTHER

Principal Investigators

• Fernando J Martinez, MD, MS · University of Massachusetts Chan Medical School

• Justin Oldham, MD, MS · University of Michigan

• Cathie Spino, DSc · University of Michigan

• Imre Noth, MD, MS · University of Virginia

• Michael Kreuter, MD · Johannes Gutenberg University Mainz

• Dinesh Khanna, MD, MS · University of Michigan

• Luca Richeldi, MD, PhD · Policlinico Gemelli

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-05-01

Primary Completion

2029-12-31

Completion

2029-12-31

Countries

• United States
• Australia
• Canada
• Ireland
• United Kingdom

Study Locations