Cognitive-Sensorimotor Function in Long-COVID
NCT06850350 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 136
Last updated 2026-05-08
Summary
Growing evidence indicates that many people who have chronic post-acute sequelae of SARS-CoV-2 infection (PASC) will experience ongoing neurological and musculoskeletal impairment that can affect gait and balance. Identifying the factors contributing to these impairments and how they influence functional mobility is the first step towards creating effective evaluation and treatment protocols. In this study the investigators will examine cognition, vision, proprioception, muscle strength, gait and balance in persons with and without PASC to understand how PASC may impact functional mobility through a cognitive-sensorimotor lens. Gait and balance will be studied in environments that stress cognitive and sensory abilities. Study outcomes will be critical for the development of evidence-based Veteran Health Administration diagnostic and standard-of-care protocols to address gait and balance dysfunction in Veterans with PASC for restoring their functional mobility and independence.
Conditions
- Post-acute Sequelae of SARS-CoV-2 Infection
Sponsors & Collaborators
-
Edward Hines Jr. VA Hospital
collaborator FED -
VA Office of Research and Development
lead FED
Principal Investigators
-
Matthew J. Major, PhD · Jesse Brown VA Medical Center, Chicago, IL
-
Keith Edward Gordon, PhD · Edward Hines Jr. VA Hospital, Hines, IL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2026-04-01
- Primary Completion
- 2030-12-31
- Completion
- 2030-12-31
Countries
- United States
Study Locations
More Related Trials
-
Non-invasive VNS for Parkinson's Gait
NCT06562569 ·Status: RECRUITING ·Phase: NA
-
Protocol: Mental Practice Combined With Physical Practice of Gait in Parkinson's Disease.
NCT03565965 ·Status: UNKNOWN ·Phase: NA
-
Mental Practice Combined With Physical Practice to Improve the Gait Performance of People With Parkinson's Disease
NCT02904837 ·Status: COMPLETED ·Phase: NA
-
Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals With Parkinson's Disease
NCT03623386 ·Status: COMPLETED ·Phase: NA
-
Comparison of Different Rehabilitation Protocols in Parkinson's Disease With Postural Instability and Gait Disorders
NCT05799690 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Exercise, Brain Imaging, Cognition, and Gait in Parkinsonism
NCT02231073 ·Status: COMPLETED ·Phase: NA
-
An Observational Study of Neurologic Function After COVID-19 Infection
NCT04564287 ·Status: COMPLETED
-
Movement Disorder Quantification Algorithm Development
NCT01534650 ·Status: COMPLETED
-
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease
NCT02458430 ·Status: COMPLETED
-
Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease
NCT07226284 ·Status: RECRUITING ·Phase: NA
-
High-intensity Functional Training on Functional and Cognitive Performance in People with Parkinson's Disease.
NCT06879821 ·Status: RECRUITING ·Phase: NA
-
The Effectiveness of Motor-motor and Motor-cognitive Dual-task Training Interventions on Balance in People With Parkinson's Disease: a Feasibility Study
NCT05710588 ·Status: UNKNOWN ·Phase: NA
-
Effect of Exercise in Parkinsonism
NCT02598973 ·Status: COMPLETED ·Phase: NA
-
Visual Function During Gait in Parkinson's Disease: Impact of Cognition and Response to Visual Cues
NCT02610634 ·Status: COMPLETED
-
Effects of Exercise on Long-Range Autocorrelations in Parkinson's Disease
NCT02419768 ·Status: UNKNOWN ·Phase: NA
-
Perception, Cognition, and Gait in Parkinson's Disease
NCT03241966 ·Status: COMPLETED
-
Effect of Haptic Cueing on Long-Range Autocorrelations in Parkinson's Disease Gait Variability
NCT05790759 ·Status: COMPLETED ·Phase: NA
-
Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.
NCT02132052 ·Status: COMPLETED
-
Longitudinal Analysis of Gait Variability to Predict Falls in Parkinson's Disease
NCT04339543 ·Status: TERMINATED ·Phase: NA
-
Investigating the Cholinergic Contribution to Gait Dysfunction in Parkinson's Disease
NCT06903910 ·Status: COMPLETED ·Phase: PHASE2
-
Effects of Inspiratory Muscle Training on Parkinson's Disease
NCT06912997 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
The Efficacy of Online Exergaming-Integrated Physiotherapy for Parkinson's Disease
NCT06317792 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Cognitive Training in Parkinson's Disease
NCT05495997 ·Status: COMPLETED ·Phase: NA
-
Microbiome Composition and Function Contributes to Cognitive Impairment and Neuroinflammation in Parkinson's Disease
NCT05419453 ·Status: RECRUITING
-
Effect of Cognitive Training on Gait in Parkinson's Disease
NCT05514379 ·Status: UNKNOWN ·Phase: NA