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Study of Nerve Injuries and Physical Exercise

NCT06846788 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2025-03-05

No results posted yet for this study

Summary

This study will explore if combining exercise with sensory training can help improve sensory function and reduce pain after an injury to the nerves in the arm and hand. The study will look at how exercise affects the BDNF protein (which helps nerves grow), how it impacts sensation, and how it might help manage pain. Research has shown that exercise is good for brain health, enhancing abilities such as focus, memory, and the ability to cope with stress. It also helps the brain release BDNF, which helps nerve cell growth and plasticity. Higher levels of BDNF might improve sensory function, but no previous study has investigated the combination of exercise and sensory training.

Study aims to investigate:

* if it is possible to use a physical exercise program (using an exercise bike) for people with nerve injuries.
* how easy it is to recruit participants, how well they stick to the program
* if exercise can change BDNF levels and VO2max (a measure of fitness), and how these changes might relate to pain and sensory.
* if it's possible to run a bigger, more detailed study in the future and check if it could be helpful for patients.

The researchers believe that combining exercise with sensory training could help reduce pain and improve sensation compared to traditional sensory training methods.

Participants will:

* perform 30 minutes of exercise on a stationary bike, twice a week, for 6 weeks at a moderate level of effort. After the exercise, they will do 5-10 minutes of sensory training, with additional exercises to practice at home. The sensory training will follow a standard program designed to help retrain the brain to process sensory information.
* be subject to a blood sample Results will include sensory function, pain evaluation, patient reported outcome measures.

Conditions

  • Nerve Injury
  • Pain Management
  • Sensorial Disturbance

Interventions

OTHER

Physical exercise

A traditional sensory relearning rehab session will be performed after our intervention consisting of 30 minutes of physical exercise.

Sponsors & Collaborators

Principal Investigators

  • Cecilia C Mellstrand Navarro, hand surgeon, ass professor · Department of Clinical Science and Education, Karolinska Institutet, Department of Hand Surgery, Södersjukhuset Hospital, and Department of Clinical Sciences Danderyd Hospital, Karolinska Institutet, Section for Orthopaedics, Stockholm, Sweden

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-01
Primary Completion
2025-08-01
Completion
2026-02-01

Countries

  • Sweden

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06846788 on ClinicalTrials.gov