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Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease

NCT06843005 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 3100

Last updated 2026-03-24

No results posted yet for this study

Summary

The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target achievement rate compared to a traditional management strategy without follow-up CCTA, thereby reducing the incidence of major adverse cardiovascular and cerebrovascular events over a 3 years period, including all-cause mortality, myocardial infarction, ischemia driven revascularation and stroke.

Conditions

  • Major Adverse Cardiovascular Events (MACE)
  • Prevention
  • Coronary Artery Disease(CAD)
  • CT Angiography

Interventions

DIAGNOSTIC_TEST

Coronary Computed Tomography Angiography

Based on the assessment of plaque progression after follow-up CCTA examination, patients will be given either intensive treatment or routine treatment.

OTHER

Current clinical guidelines

Patients will be treated according to the 2024 ESC Guidelines for the Management of Chronic Coronary Syndromes.

Sponsors & Collaborators

  • Zhang longjiang,MD

    lead OTHER

Principal Investigators

  • Trail Manager · Jinling Hospital,Nanjing University School of Medicine,Nanjing,China

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-28
Primary Completion
2028-12-30
Completion
2028-12-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06843005 on ClinicalTrials.gov