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Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults

NCT06842784 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2025-02-24

No results posted yet for this study

Summary

Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.

Conditions

  • Aging
  • Heat Stress
  • Hyperthermia
  • Heat Strain

Interventions

OTHER

Ambient heat stress

3-hour ambient heating in 44°C and 20% relative humidity

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • The American Society of Echocardiography

    collaborator UNKNOWN

  • University of Texas Southwestern Medical Center

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-03
Primary Completion
2026-02-01
Completion
2027-02-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06842784 on ClinicalTrials.gov