MedTrace Logo

Bronchodilators and Lung Mechanics During Exercise in COPD

NCT06825013 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2025-02-13

No results posted yet for this study

Summary

Bronchodilators are medications that open the bronchi to help patients with COPD to breathe better. It is still not known exactly how this effect improves shortness of breath in people with COPD. The goal of this clinical trial is to determine whether bronchodilators lower resistance in the smallest airways in the lungs, and whether this will improve the feeling of breathlessness in these patients.

The main questions the investigators attempt to answer are:

* In patients with COPD, does treatment with a short-acting bronchodilator improve small airway resistance during exercise?
* In patients with COPD, does acute treatment with short-acting bronchodilator improve breathlessness and exercise endurance?

The investigators will compare short-acting bronchodilators to placebo (a substance that contains no drug) to see if the bronchodilator medications improve small airway resistance and breathlessness during exercise.

Participants will:

* Visit the research laboratory 3 visits to complete tests of lung function and exercise
* Complete 2 identical visits (Visit 2 and 3), one in which the participant receives bronchodilator and one in which the participant receives placebo.

Conditions

Interventions

DRUG

Bronchodilators inhalation

Salbutamol sulphate (2.5 mg) + ipratropium bromide (0.5 mg)

DRUG

Placebo

Nebulized saline

Sponsors & Collaborators

  • Dr. J. Alberto Neder

    lead OTHER

Principal Investigators

  • J Alberto Neder, MD, PhD · Queen's University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-11-10
Primary Completion
2027-01-31
Completion
2027-01-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06825013 on ClinicalTrials.gov