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Exploring the Landscape of Injury and Repair in the Human Oesophagus

NCT06820151 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-02-11

No results posted yet for this study

Summary

The goal of this study limited to working with human tissue samples is to delineate the mechanisms defining appropriate oesophageal injury and repair and to use this information to understand how these rules are dysregulated and result in cancer formation in adult patients undergoing endoluminal vacuum therapy (EVT therapy) for the treatment of perforations to the oesophagus.

The main question\[s\] it aims to answer are:

* to gain a deeper understanding of the processes underlying tissue regeneration and repair in the oesophagus and upper gastro-intestinal tract following physical injury
* to identify the similarities in the processes of regeneration and early carcinogenesis

Participants will take part in the study during their usual EVT therapy schedule. Tissue brushings and pinch biopsies will also be taken.

Conditions

  • Perforations to the Oesophagus

Interventions

OTHER

Sample collection

Sample collection: EVT sponges, tissue brushings and pinch biopsies

Sponsors & Collaborators

  • The Wellcome Sanger Institute

    lead OTHER

Principal Investigators

  • AYESHA NOORANI, PhD MRCS · Genome Research Limited operating as The Wellcome Sanger Institute

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2026-04-29
Completion
2026-04-29

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06820151 on ClinicalTrials.gov