CRF2 Agonist for the Treatment of Worsening Heart Failure
NCT06815471 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 300
Last updated 2026-04-08
Summary
This study assesses the effects of the investigational drug COR-1167 in subjects hospitalised due to worsening of heart failure (HF)
Conditions
- Worsening Heart Failure
Interventions
- DRUG
-
COR-1167
28-day treatment
- DRUG
-
28-day treatment
Sponsors & Collaborators
-
Worldwide Clinical Trials
collaborator OTHER -
Corteria Pharmaceuticals
lead INDUSTRY
Principal Investigators
-
Jeffrey Testani, MD · Yale University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 85 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-08-07
- Primary Completion
- 2026-12-31
- Completion
- 2026-12-31
- FDA Drug
- Yes
Countries
- United States
- Czechia
- Georgia
- Hungary
- Poland
- Romania
- Serbia
- Spain
Study Locations
More Related Trials
-
Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
NCT06215586 ·Status: COMPLETED ·Phase: PHASE2
-
Interleukin-1 Blockade in HF With Preserved EF
NCT02173548 ·Status: COMPLETED ·Phase: PHASE2
-
Beta 3 Agonist Treatment in Heart Failure
NCT01876433 ·Status: COMPLETED ·Phase: PHASE2
-
Randomized Clinical Trial to Evaluate the Regenerative Capacity of CardioCell in Patients With Chronic Ischaemic Heart Failure (CIHF)
NCT03418233 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
NCT06979375 ·Status: RECRUITING ·Phase: PHASE2
-
Impact of Vericiguat on Hemodynamics of Heart Failure
NCT05704478 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Metabolic Manipulation in Chronic Heart Failure
NCT00841139 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)
NCT06215911 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Learn How Well the Drug Vericiguat Works and How Safe it is Under Real World Conditions in Indian Participants After Worsening of a Long-term Heart Condition in Which the Left Side of the Heart Does Not Pump Blood as Well as it Should (Chronic Heart Failure With Reduced Ejection Fraction)
NCT05658458 ·Status: COMPLETED ·Phase: PHASE4
-
An Observational Study to Learn More About Vericiguat Treatment Patterns and Its Safety in People With Chronic Heart Failure With Reduced Ejection Fraction in Routine Medical Care in the United States
NCT06363110 ·Status: COMPLETED
-
A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure
NCT02157506 ·Status: COMPLETED ·Phase: PHASE2
-
Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction
NCT06717204 ·Status: NOT_YET_RECRUITING
-
Beta 3 Agonist Treatment in Heart Failure-2
NCT03926754 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Effect of Carvedilol Rapid Up-Titration in Patients With Heart Failure With Reduced Ejection Fraction
NCT05179070 ·Status: UNKNOWN ·Phase: PHASE4
-
Pirfenidone to Treat Hypertrophic Cardiomyopathy
NCT00011076 ·Status: COMPLETED ·Phase: PHASE2
-
Developing Oral LT3 Therapy for Heart Failure - HFrEF
NCT04112316 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF
NCT02589977 ·Status: COMPLETED ·Phase: PHASE4
-
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
NCT06979362 ·Status: RECRUITING ·Phase: PHASE2
-
Harefield Recovery Protocol Study for Patients With Refractory Chronic Heart Failure
NCT00585546 ·Status: TERMINATED ·Phase: PHASE1
-
Stratified Treatment to Ameliorate Diastolic Left Ventricular Stiffness in Heart Failure With Preserved Ejection Fraction
NCT04475042 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction
NCT07269717 ·Status: RECRUITING ·Phase: PHASE2
-
Effectiveness of CRD-740 in Heart Failure
NCT05409183 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Real-world Events of Vericiguat in Patients With Chronic Kidney Disease and Heart Failure
NCT07047547 ·Status: RECRUITING ·Phase: NA
-
ERtugliflozin triAl in DIabetes With Preserved or Reduced ejeCtion FrAcTion mEchanistic Evaluation in Heart Failure
NCT03416270 ·Status: COMPLETED ·Phase: PHASE2
-
Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients
NCT01541202 ·Status: TERMINATED ·Phase: PHASE3