Transcriptional Framework for the Molecular Diagnosis of Response to Immunotherapy in Lung Cancer With Agnostic Potential
NCT06807307 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 256
Last updated 2025-02-04
Summary
Through genomic and transcriptomic sequencing techniques (whole exome sequencing, WES; whole transcriptome sequencing, WTS) patients with enrichment for KEAPness and specific gene interactions associated with it.
Conditions
Sponsors & Collaborators
-
Regina Elena Cancer Institute
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-06-04
- Primary Completion
- 2026-06-04
- Completion
- 2026-06-04
Countries
- Italy
Study Locations
More Related Trials
-
The Recurrence Gene Profiles of Adjuvant Osimertinib Therapy in Resected Non-Small-Cell Lung Cancer
NCT06477055 ·Status: RECRUITING
-
Efficacy Study of Osimertinib in Treatment-naïve Patients With EGFR Mutant NSCLC According to TP53 Mutational Status.
NCT05785208 ·Status: RECRUITING ·Phase: PHASE4
-
A Study to Evaluate the Safety and Dosimetry of 68Ga-labelled OncoFAP Derivatives in Solid Tumors
NCT05784597 ·Status: COMPLETED ·Phase: PHASE1
-
NGS Combined With RNAseq on Tumor Immune Escape in NSCLC
NCT03764917 ·Status: UNKNOWN
-
Study of ABT-869 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)
NCT00517790 ·Status: COMPLETED ·Phase: PHASE2
-
Identification of EGFR-TKIs Sensitivity or Resistance Markers in NSCLC May Help in Optimal Patient Selection
NCT00831454 ·Status: COMPLETED
-
An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors
NCT02616211 ·Status: COMPLETED
-
Prospective Study on Resistance-associated Mutations in Metastatic Lung Cancer
NCT06081270 ·Status: RECRUITING
-
Glycoprotein in Immunotherapy Response and Efficacy Prediction of Lung Cancer
NCT06730503 ·Status: RECRUITING
-
Best EGFR-TKI Sequence in NSCLC Harboring EGFR Mutations
NCT04811001 ·Status: UNKNOWN ·Phase: PHASE2
-
Molecular Diagnosis on Circulating Tumor DNA of Non-Small Cell Lung Cancer
NCT02169349 ·Status: COMPLETED
-
Exosomes Detection for the Prediction of the Efficacy and Adverse Reactions of Anlotinib in Patients With Advanced NSCLC
NCT05218759 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Study for Patients With Lung Metastatic Advanced Gastric Cancer and NSCLC Treated With Apatinib
NCT03629691 ·Status: COMPLETED
-
A Prospective Study Investigating the Relationship Between Minimal Residual Disease Detection, Monitoring Frequency, and Prognosis in Non-small Cell Lung Cancer Patients Eligible for Curative Treatment.
NCT06854939 ·Status: NOT_YET_RECRUITING
-
Overcoming Resistance to EGFR Neutralization by Combination of Monoclonal Antibodies and Novel Cancer Drugs
NCT06863818 ·Status: ACTIVE_NOT_RECRUITING
-
Retrospective Study in Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR)
NCT02293733 ·Status: COMPLETED
-
R115777 in Treating Patients With Recurrent or Metastatic Non-small Cell Lung Cancer
NCT00005989 ·Status: COMPLETED ·Phase: PHASE2
-
Registry for Patients With Acquired Resistance to Small Molecule Kinase Inhibitors in Non-Small-Cell Lung Cancer
NCT00579683 ·Status: COMPLETED
-
Correlation Between Efficacy of Osimertinib and EGFR T790M Status and Ratio Via ddPCR in NSCLC
NCT05458726 ·Status: UNKNOWN ·Phase: PHASE2
-
NGS-based Large-panel in Targeted Drug Delivery and Immunotherapy of Lung Cancer
NCT04159337 ·Status: UNKNOWN
-
Study of Blood and Tissue Samples in Predicting Response to Second-Line Therapy Using Erlotinib Hydrochloride or Chemotherapy in Patients With Advanced Non-Small Cell Lung Cancer
NCT00989690 ·Status: UNKNOWN ·Phase: PHASE3
-
Osimertinib Combined With Bevacizumab in Patients With Brain Metastasis Epidermal Growth Factor Receptor (EGFR) Mutation Positive Metastatic Non-Small Cell Lung Cancer
NCT05104281 ·Status: UNKNOWN ·Phase: PHASE3
-
First Line Bio-immunotherapy With Thymosin Alpha 1 in Patients With Sensitizing EGFR Mutation Positive Non Small Cell Lung Cancer Who Are Taking Standard of Care Therapy
NCT02906163 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
The Combination of Anlotinib and Immune Checkpoint Inhibitors for Advanced NSCLC Patients With Muti-line Therapy
NCT04670107 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Development of a Model to Predict Progression-Free Survival After Erlotinib in Patients With Non-Small Cell Lung Cancer
NCT00897533 ·Status: COMPLETED