An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors
NCT02616211 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 15
Last updated 2020-10-19
Summary
Patients are asked to participate in this study if they have been diagnosed with a thoracic carcinoma which includes lung cancer and have a gene mutation (alteration in the body's genetic instructions) and after undergoing treatment the cancer has come back, progressed, or shown a partial response on standard treatment.
Conditions
- Adenocarcinoma of Lung
- Lung Neoplasm
- Cancer of Lung
- Lung Cancer
- Pulmonary Cancer
- EGFR Genes
- ALK Genes
Sponsors & Collaborators
-
National Foundation for Cancer Research
collaborator OTHER - lead OTHER
Principal Investigators
-
Jin Jen, MD, PhD · Mayo Clinic
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-10-31
- Primary Completion
- 2018-10-31
- Completion
- 2019-12-31
Countries
- United States
Study Locations
More Related Trials
-
Acquired Resistant Mechanism of the First-generation EGFR TKIs
NCT02804217 ·Status: UNKNOWN
-
A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer
NCT03131206 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Resistance & Activating Mutations Diagnosed Among NSCLC Community Dwelling EGFR Mutation Positive Patients
NCT03137264 ·Status: COMPLETED
-
A Study of EGF816 and Gefitinib in TKI-naïve EGFR-mutant Non-Small Cell Lung Cancer
NCT03292133 ·Status: TERMINATED ·Phase: PHASE2
-
Phase I/II Study of Chemoprevention With EGFR and COX-2 Inhibitor
NCT00314262 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Retrospective Study in Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR)
NCT02293733 ·Status: COMPLETED
-
Local Therapies for Oligometastatic Non-Small Cell Lung Cancer Harboring Sensitizing EGFR Mutations
NCT02450591 ·Status: COMPLETED ·Phase: NA
-
Phase III Study (Tarceva®) vs Chemotherapy to Treat Advanced Non-Small Cell Lung Cancer in Patients With Mutations in the TK Domain of EGFR
NCT00446225 ·Status: COMPLETED ·Phase: PHASE3
-
TKI Followed by Thoracic Radiotherapy for Stage IV EGFR Mutant NSCLC
NCT03916913 ·Status: UNKNOWN ·Phase: NA
-
A Study of Tiragolumab in Combination With Atezolizumab in Chemotherapy-Naïve Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
NCT03563716 ·Status: COMPLETED ·Phase: PHASE2
-
Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases
NCT02616393 ·Status: COMPLETED ·Phase: PHASE2
-
Continuation of TKI With or Without Chemotherapy Beyond Gradual Progression
NCT01998061 ·Status: UNKNOWN ·Phase: PHASE2
-
First Line Bio-immunotherapy With Thymosin Alpha 1 in Patients With Sensitizing EGFR Mutation Positive Non Small Cell Lung Cancer Who Are Taking Standard of Care Therapy
NCT02906163 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT00536107 ·Status: TERMINATED ·Phase: PHASE4
-
A Study of Hypofractionated Radiotherapy for Limited Metastatic NSCLC Harboring Sensitizing EGFR Mutations After First Line TKI Therapy
NCT02788058 ·Status: UNKNOWN ·Phase: PHASE2
-
Epidermal Growth Factor Receptor and K-ras Mutations in Patients With Stage III Non-Small Cell Lung Cancer
NCT00898924 ·Status: COMPLETED
-
Alflutinib Versus Alflutinib Plus Chemotherapy for NSCLC
NCT05209256 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
De Novo Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors
NCT01697163 ·Status: UNKNOWN
-
Weekly Use First-generation EGFR-TKI in the Treatment of EGFR-TKI Acquired Resistance Non-small Cell Lung Cancer (NSCLC)
NCT02575560 ·Status: COMPLETED
-
AZD9291 Versus Gefitinib or Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT02296125 ·Status: COMPLETED ·Phase: PHASE3
-
Concurrent EGFR-TKIs and Thoracic Radiation Therapy in Active EGFR Mutation for 1st Line Treatment of Stage IV NSCLC
NCT02353741 ·Status: TERMINATED ·Phase: PHASE2
-
A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated, c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment
NCT01610336 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib and Momelotinib for the Treatment of Epidermal Growth Factor Receptor (EGFR) Mutated EGFR Tyrosine Kinase Inhibitor (TKI) Naive Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT02206763 ·Status: TERMINATED ·Phase: PHASE1
-
Can Epidermal Growth Factor Receptor Improve the Postoperative Survivorship for Inoperable Non-small Cell Lung Cancer With Spinal Metastasis ?
NCT02740894 ·Status: COMPLETED
-
ALK Tyrosine Kinase Inhibitors in ALK-rearranged Advanced Squamous Cell Carcinoma
NCT05014464 ·Status: RECRUITING ·Phase: PHASE2