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Predicting Manifest Astigmatism in Keratoconus Patients.

NCT06798779 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 800

Last updated 2025-01-29

No results posted yet for this study

Summary

The cornea of the human eye has several functions. It is transparent to allow light into the eye and its shape focuses the incoming light onto the retina. The cornea is responsible for two-thirds of this focusing, while the human lens accounts for the remaining third.

Keratoconus is a condition with onset in the second to third decades of life, where the cornea warps into an irregular shape. This irregularity reduces vision due to blurring of the image focused on the retina. Only partial improvement is achievable with traditional glasses because the corneal shape becomes irregular.

The glasses prescriptions of patients with keratoconus often differ significantly from the measurements obtained from the cornea in a clinical setting. The predictability of the magnitude and variability of this disparity is poorly understood. As a result, determining the optimal glasses prescription for achieving the best vision correction often involves a time-consuming trial-and-error approach. Improved predictability could reduce the time required to identify the optimal glasses prescription, thereby increasing productivity. For surgical patients, better predictability would enable surgeons to select lenses that provide superior vision outcomes after treatment. In the optometry clinic at the West of England Eye Unit, a database of over 800 patients with glasses prescriptions and corresponding corneal scans has been compiled by the investigators. This is a sufficient dataset to train and assess the prediction accuracy of machine learning models (AI) of glasses measurements using corneal scan parameters as predictor variables.

Conditions

  • Keratoconus
  • Keratoconus, Artificial Intelligence, Support Vector Machine

Interventions

DEVICE

Glasses

The patients will have had their vision corrected with glasses that may contain both spherical and cylindrical corrections. The glasses prescription that offers the best subjective correction of vision are being recorded.

DIAGNOSTIC_TEST

Corneal topography

This is a scan of the cornea (front of the eye). This gives us information on how the cornea is refracting light for the patient.

Sponsors & Collaborators

  • Royal Devon and Exeter NHS Foundation Trust

    lead OTHER

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-01
Primary Completion
2025-05-31
Completion
2025-05-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06798779 on ClinicalTrials.gov