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Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?

NCT06795984 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2025-01-28

No results posted yet for this study

Summary

This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.

Conditions

  • Pregnancy Rate IVF
  • Blastocyst IVF

Interventions

OTHER

Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes

The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts.

Sponsors & Collaborators

  • Calla IVF Center

    lead OTHER

Eligibility

Min Age
21 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-12
Primary Completion
2024-08-15
Completion
2024-12-11

Countries

  • Romania

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06795984 on ClinicalTrials.gov