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Measuring Hydrogen Peroxide in Exhaled Breath Condensate in COPD

NCT06788457 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-01-23

No results posted yet for this study

Summary

Following a successful pilot study and a clinical assessment in healthy volunteers (ClinicalTrials.gov ID: NCT05844553) this study aims to evaluate the accuracy and precision of an Exhaled Breath Condensate (EBC) device in patients with COPD. The study will evaluate the reproducibility of 3 measurements a month apart in real breath samples. This will take place at the Clinical Research Facility (CRF) at the Royal Brompton Hospital. Real biological specimens are complex and there is the potential for losses of precision and accuracy. This can only be evaluated by comparison with established methodology. Secondly, whilst many reports can correctly classify COPD patients, there are substantial variations in absolute levels between researchers. It has been shown with artificial samples that correcting for variations in heat and mass transport can substantially reduce these variations. Collecting replicate samples from patients with COPD will allow the evaluation within this patient group.

Conditions

  • Proof of Concept Study

Interventions

DEVICE

Exhaled Breath Condensate

Measurement of hydrogen peroxide in exhaled breath

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Omar Usmani, MBBS, MRCP, PhD · Imperial College London

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-10
Primary Completion
2022-10-12
Completion
2022-10-12

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06788457 on ClinicalTrials.gov