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Home High Flow Oxygen to Reduce Acute Exacerbation of COPD

NCT05196698 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 406

Last updated 2026-02-06

No results posted yet for this study

Summary

The objective of the study is to evaluate the efficacy of home High Flow Oxygen for the reduction of severe exacerbation following admission for a severe exacerbation of COPD or death against standard oxygen therapy.

Conditions

Interventions

OTHER

High Flow Oxygen Therapy

HFOT will be delivered validated medical devices and established as follow: * Patient will be acclimatized to HFOT which will aim to achieve a flow of air of 30L/min at a temperature of 34°C using dedicated nasal canula. * Once patient acclimatized, oxygen will be entrained in the HFOT device at a flow that will aim to achieve a saturation \> 90%. An arterial blood gas will be performed with such oxygen delivery, flowrate and temperature to ensure a PaO2 ≥ 8kPa

OTHER

Long-term oxygen therapy

LTOT delivery will be performed according to French guidelines

Sponsors & Collaborators

  • University Hospital, Rouen

    lead OTHER

Principal Investigators

  • Antoine CUVELIER, Pr · University Hospital, Rouen

  • Maxime PATOUT, Dr · AP-HP La Pitié Salpétrière

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-26
Primary Completion
2026-08-26
Completion
2026-08-26

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05196698 on ClinicalTrials.gov