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Communicating About Nicotine Reduction in Cigarettes

NCT06787937 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1230

Last updated 2025-10-29

No results posted yet for this study

Summary

The goal of this clinical trial is to learn how a messaging campaign about reduced nicotine cigarettes and policy, combined with the use of very low nicotine cigarettes (VLNCs), affects smoking behavior and attitudes among adult smokers. The study also aims to assess the efficacy of the messages in different populations, including smokers with past-month serious psychological distress (SPD), low socioeconomic status (SES), and those in neither category.

The primary hypothesis is: exposure to messages in combination with VLNC use will lead to less cigarettes use compared to VLNCs without messages.

Researchers will compare: The effects of receiving VLNCs with messages (treatment group) to receiving VLNCs without messages (control group).

Participants will: Complete a baseline survey and be randomly assigned to one of two groups: treatment (VLNCs + messages) or control (VLNCs only). Attend weekly study visits for surveys, breath samples, and receive supply of VLNCs , either with or without the messaging campaign. Complete brief daily surveys through text messages.

Conditions

  • Tobacco Products
  • Smoking Behavior
  • Cigarette Use

Interventions

BEHAVIORAL

VLNC messages

Participants will be exposed to messaging about VLNCs and reduced nicotine policy through multiple formats, including inserts placed in cigarette packs, printed advertisements, and video materials presented during their weekly visits.

BEHAVIORAL

Control message

Participants will be exposed to control messages, such as advertisements for bottled water, during their weekly visits.

Sponsors & Collaborators

  • Emory University

    collaborator OTHER

  • University of South Carolina

    collaborator OTHER

  • National Cancer Institute (NCI)

    collaborator NIH

  • Georgia State University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-11
Primary Completion
2029-01-31
Completion
2029-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06787937 on ClinicalTrials.gov