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STI Prophylaxis and Emergence of Antimicrobial Resistance

NCT06778083 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 108

Last updated 2025-03-27

No results posted yet for this study

Summary

The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted infections (STI prophylaxis, doxycycline post-exposure prophylaxis, or 'doxyPEP'). The study will assess how easy and acceptable it is to find antibiotic resistance and microbiome changes in the throats and guts of men-who-have-sex-with-men (MSM) who use STI prophylaxis.

The study will recruit 108 MSM who are using and not using STI prophylaxis. Participants will visit the clinic every 6 months. At each visit, they will provide a throat swab and stool sample, and complete a questionnaire. DNA of the bacteria from the samples will be analysed to identify the bacteria and look for antibiotic resistance.

Conditions

  • Sexually Transmitted Infection (STI) Prevention
  • Antibiotic Prophylaxis
  • Antibiotic Resistance, Bacterial
  • Microbiome
  • Doxycycline

Sponsors & Collaborators

  • University of Oxford

    collaborator OTHER

  • University College, London

    lead OTHER

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-10
Primary Completion
2027-04-30
Completion
2027-04-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06778083 on ClinicalTrials.gov