SLV-154 Treatment of Metastatic Solid Tumors
NCT06771219 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 70
Last updated 2026-01-23
Summary
This is a Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and efficacy of SLV-154 across a range of dose levels when administered to subjects with metastatic solid tumors.
Conditions
- Squamous Cell Cancer of Head and Neck (SCCHN)
- NSCLC
- SCLC
- Cervical Cancer Metastatic
- Breast Cancer Metastatic
- Endometrial Cancer
- Ovarian Cancer
- Urothelial Cancer
- Sarcoma
- Thyroid Cancer
Interventions
- DRUG
-
SLV-154
SLV-154
Sponsors & Collaborators
-
Solve Therapeutics
lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-05-14
- Primary Completion
- 2027-01-31
- Completion
- 2027-04-30
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Sorafenib in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery
NCT00119249 ·Status: COMPLETED ·Phase: PHASE2
-
Pharmacokinetic Study of Liposomal Vincristine in Patients With Malignant Melanoma & Hepatic Dysfunction
NCT00145041 ·Status: COMPLETED ·Phase: PHASE1
-
Sorafenib in Treating Patients With Advanced Malignant Solid Tumors
NCT00810394 ·Status: COMPLETED ·Phase: PHASE2
-
Bortezomib With or Without Irinotecan in Treating Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
NCT00103259 ·Status: COMPLETED ·Phase: PHASE2
-
NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma
NCT06420349 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of TAVO412 in Patients with Cancer
NCT05548634 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Study Evaluating Temsirolimus in Advanced Stage Squamous Cell Carcinoma of the Head & Neck
NCT00195299 ·Status: COMPLETED
-
Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus
NCT01822522 ·Status: COMPLETED ·Phase: PHASE1
-
Sorafenib Tosylate and Hypoxia-Activated Prodrug TH-302 in Treating Patients With Advanced Kidney Cancer or Liver Cancer That Cannot Be Removed By Surgery
NCT01497444 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluating Efficacy of Tivozanib (AV-951) in Biliary Tract Cancers
NCT04645160 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma
NCT00733798 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Cabozantinib-S-Malate and Vemurafenib in Treating Patients With Solid Tumors or Melanoma That is Metastatic or That Cannot Be Removed By Surgery
NCT01835184 ·Status: TERMINATED ·Phase: PHASE1
-
A Study to Evaluate RAF265, an Oral Drug Administered to Subjects With Locally Advanced or Metastatic Melanoma
NCT00304525 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer
NCT06931626 ·Status: RECRUITING ·Phase: PHASE1
-
Veliparib and Irinotecan Hydrochloride in Treating Patients With Cancer That Is Metastatic or Cannot Be Removed by Surgery
NCT00576654 ·Status: COMPLETED ·Phase: PHASE1
-
Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma
NCT00245102 ·Status: COMPLETED ·Phase: PHASE2
-
Treatment for Subjects With Unresectable Stage III or Stage IV Melanoma
NCT00110994 ·Status: COMPLETED ·Phase: PHASE2
-
S9624 Ifosfamide in Treating Patients With Meningeal Tumors
NCT00003292 ·Status: TERMINATED ·Phase: PHASE2
-
SU5416 in Treating Patients With Malignant Mesothelioma
NCT00006014 ·Status: COMPLETED ·Phase: PHASE2
-
17-AAG and Sorafenib in Treating Patients With Unresectable or Metastatic Solid Tumors
NCT00121264 ·Status: COMPLETED ·Phase: PHASE1
-
SU5416 in Treating Patients With Advanced or Recurrent Cancer of the Head and Neck
NCT00006361 ·Status: COMPLETED ·Phase: PHASE2
-
Nanoparticle Albumin-Bound Rapamycin in Treating Patients With Advanced Cancer With mTOR Mutations
NCT02646319 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma
NCT00720174 ·Status: COMPLETED ·Phase: PHASE1
-
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
NCT03652077 ·Status: COMPLETED ·Phase: PHASE1
-
SU5416 in Treating Patients With Advanced Solid Tumors
NCT00005642 ·Status: COMPLETED ·Phase: PHASE1