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Comparison Between Different Sampling Sites for Detection of Respiratory Viruses

NCT06743750 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 501

Last updated 2025-07-04

No results posted yet for this study

Summary

The goal of this observational study is to validate the use of less invasive samples (saliva, orobuccal or nasal swabs) than nasopharyngeal swab for testing common and clinically relevant respiratory viruses in children and adults presenting to an emergency departements with symptoms compatible with respiratory tract infection. The main question it aims to answer is:

\- Is the precision of reverse transcription polymerase chain reaction (RT-PCR) for Influenzavirus A or B, respiratory syncytial virus (RSV), and Rhinovirus, on saliva, orobuccal swabs and nasal swabs comparable to the gold standard nasopharyngeal swab in a pediatric and adult population presenting with symptoms compatible with respiratory tract infection.

Among participants the following samples will be collected (nasopharyngeal swab is standard of care and not part of the study samples):

* Saliva
* Orobuccal swab
* Nasal swab

Conditions

  • Respiratory Tract Infection Viral

Interventions

DIAGNOSTIC_TEST

RT-PCR in different respiratory tract samples

RT-PCR on saliva, orrobuccal swab and nasal swab will be performed. Nasopharyngeal swab will be performed independently of the study as standard of care.

Sponsors & Collaborators

  • University of Bern

    collaborator OTHER

  • Roche Diagnostics GmbH

    collaborator INDUSTRY

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Philipp Jent, MD · University Hospital of Bern, University of Bern

Eligibility

Min Age
0 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-19
Primary Completion
2025-06-20
Completion
2025-06-20

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06743750 on ClinicalTrials.gov