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Study of Sleep Inertia in Major Depressive Disorder by the Psychomotor Vigilance Task

NCT06732284 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2025-12-11

No results posted yet for this study

Summary

The study population comprises three groups of 30 analyzable participants: Patients with sleep inertia and Major Depressive Disorder, patients with Major Depressive Disorder but without sleep inertia, and controls without mood disorders or sleep inertia. Controls will be patients referred to the Sleep Disorders and Acupuncture Unit for polysomnography as part of the screening process for a sleep disorder. Only controls presenting an apnea-hypopnea index \< 15/h, a periodic leg movements index during sleep \< 15/h and a total sleep time ≥ 6 hours on the video-polysomnography will be analyzed.

Conditions

Interventions

OTHER

Psychomotor vigilance task

Five PVT tests (before sleep at 7pm, 7am, 7:30am, 8am and 11am). The PVT is a 10-minute test designed to assess the vigilance and sustained attention by measuring reaction times (RT) to visual stimuli. During the test, participants are required to monitor the computer screen and press the response button as soon as a millisecond counter appears which will stop the counter and display the RT in milliseconds. The stimuli are randomly presented.

OTHER

Video-polysomnography

Performed overnight as part of routine care (11 p.m. to 7 a.m.).

OTHER

Sleep and activity monitoring

Actimeter and sleep diary to assess the sleep-wake patterns of the participants in their natural environments over a two-week period.

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Nīmes

    lead OTHER

Principal Investigators

  • Elisa EVANGELISTA · CHU de Nimes

Eligibility

Min Age
18 Years
Max Age
54 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-11-04
Primary Completion
2027-03-31
Completion
2027-03-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06732284 on ClinicalTrials.gov