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Heat Shock Protein 47 in Thrombosis

NCT06731673 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 340

Last updated 2025-08-21

No results posted yet for this study

Summary

The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial infarction (AMI) or ischaemic stroke compared to healthy volunteers. The main questions it aims to answer are:

1. Are platelet levels of HSP47 higher in patients with acute VTE, AMI or stroke, compared to healthy volunteers.
2. Does platelet levels of HSP47 remain elevated in patients with acute thrombotic events compared to healthy volunteers at 3 and 12-months of follow-up.
3. Are platelet levels of HSP47 postively associated with platelet function and negatively associated with fibrinolytic capacity in patients with an acute thrombotic event.

Participants with VTE, AMI or stroke will be giving a blood sample at diagnosis and again after 3 and 12 months of follow-up. Healthy volunteers will be giving a blood sample once.

Conditions

  • Venous Thromboembolism (VTE)
  • Acute Myocardial Infarction With ST Segment Elevation
  • Stroke (in Patients With Atrial Fibrillation)

Sponsors & Collaborators

  • Aarhus University Hospital

    collaborator OTHER

  • Max Planck Institute of Biochemistry

    collaborator UNKNOWN

  • Deutsches Herzzentrum der Charité, Berlin

    collaborator UNKNOWN

  • University of Aarhus

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-12-09
Primary Completion
2027-08-31
Completion
2027-08-31

Countries

  • Denmark
  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06731673 on ClinicalTrials.gov