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Prevention of Atrial Fibrillation After Cardiac Surgery by Pericardiotomy

NCT06728826 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 650

Last updated 2026-07-14

No results posted yet for this study

Summary

PRINCE-CH is a multicentre, randomized controlled trial which evaluates the effectiveness and safety of posterior pericardiotomy in preventing POAF after cardiac surgery in Chinese population.

Conditions

  • Atrial Fibrillation (AF)
  • Cardiac Events
  • Pericardial Effusion

Interventions

PROCEDURE

Posterior pericardiotomy

The surgeon will perform a posterior pericardiotomy while the patient is on cardiopulmonary bypass. In detail, a 4-cm opening in the posterior pericardium will be made with a cautery between the left inferior pulmonary vein and the diaphragm. Then a soft channel drain will be placed through the opening in pericardium with the tip into the left pleural space.

Sponsors & Collaborators

  • The General Hospital of Northern Theater Command

    collaborator OTHER

  • Changhai Hospital

    lead OTHER

Principal Investigators

  • Lin Han, M.D. Ph.D. · Naval Medical University Changhai Hospital

  • Huishan Wang, M.D. Ph.D. · The General Hospital of Northern Theater Command

  • Hao Zhang, M.D. Ph.D. · Naval Medical University Changhai Hospital

  • Yuji Zhang, M.D. Ph.D. · The General Hospital of Northern Theater Command

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-12-31
Completion
2027-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06728826 on ClinicalTrials.gov