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Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia

NCT06726395 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 420

Last updated 2026-04-30

No results posted yet for this study

Summary

The goal of this study is to investigate if benzylpenicillin is a better treatment option than cloxacillin in patients with penicillin-susceptible Staphylococcus aureus bacteraemia.

Conditions

  • Staphylococcus Aureus Bacteraemia
  • Staphylococcal Bacteraemia
  • Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
  • Staphylococcus (S.) Aureus Infection

Interventions

DRUG

Penicillin G_1200mg

benzylpenicillin preferred dosing 1gx4

DRUG

cloxacillin

cloxacillin 2gx4

Sponsors & Collaborators

  • Region Skane

    lead OTHER

Principal Investigators

  • Malin Hagstrand Aldman, PhD, MD · Lund University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-10
Primary Completion
2028-04-30
Completion
2028-07-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06726395 on ClinicalTrials.gov