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GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification

NCT06722521 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 7435

Last updated 2025-08-07

No results posted yet for this study

Summary

A Multicenter, randomized trial comparing the efficacy and safety of intensive lipid-lowering therapy using a statin-ezetimibe combination without aspirin versus statin monotherapy with aspirin in asymptomatic patients with coronary artery calcification

Conditions

  • Primary Prevention
  • Vascular Calcification

Interventions

DRUG

Pitavastatin 4mg and ezetimibe 10mg, taken once daily

Intensive lipid-lowering therapy without aspirin

DRUG

Pitavastatin 2 mg with aspirin 100 mg, taken once daily.

Moderate-intensity lipid-lowering therapy with aspirin

Sponsors & Collaborators

  • Asan Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-09
Primary Completion
2032-06-30
Completion
2032-10-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06722521 on ClinicalTrials.gov