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Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium

NCT06714149 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2024-12-03

No results posted yet for this study

Summary

The investigators want to study the effect of environmental nitrogen enrichment on the allergy burden in pollen-sensitized subjects.

Conditions

  • Pollen Allergy

Interventions

DIAGNOSTIC_TEST

Immunoreactivity testing

Blood samples will be collected and used to determine the intensity of the allergenicity of the subject toward different types of pollen. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.

DIAGNOSTIC_TEST

Immunoreactivity testing (negative control)

Blood samples will be collected and used to determine the background activity of our immunoreactivity tests. The investigators will use samples from negative controls to demonstrate that non-allergic individuals do not react to our assays, confirming that our pollen extracts have no background reactivity. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.

Sponsors & Collaborators

  • Sciensano

    collaborator OTHER_GOV

  • KU Leuven

    collaborator OTHER

  • University of Namur

    collaborator OTHER

  • Université Catholique de Louvain

    collaborator UNKNOWN

  • prof. dr. Rik Schrijvers

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-29
Primary Completion
2025-02-28
Completion
2025-04-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06714149 on ClinicalTrials.gov