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Silver Nitrate vs. Triamcinolone for Treatment of Hypergranulation Tissue

NCT06681194 · Status: WITHDRAWN · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL

Last updated 2026-07-22

No results posted yet for this study

Summary

This randomized controlled trial aims to compare the efficacy of silver nitrate, triamcinolone, and a successive use of both treatments in managing hypergranulation tissue in traumatic wounds. Conducted over a four-year period at UPMC Mercy, the study will involve patients presenting with hypergranulation tissue. Participants will be randomly assigned to receive either topical silver nitrate, topical triamcinolone, or a combination of the two in succession. The study will assess treatment outcomes based on the reduction or resolution of hypergranulation tissue, with the goal of identifying the most effective therapeutic approach. This research will provide valuable insights into optimizing treatment strategies for hypergranulation tissue in traumatic wounds.

Conditions

  • Wound Healing
  • Granulation Tissue

Interventions

DRUG

Silver Nitrate

See "Silver nitrate only" study arm

DRUG

triamcinolone

See "Triamcinolone only" study arm

DRUG

Silver nitrate + triamcinolone

See "Combination group" study arm

Sponsors & Collaborators

  • Francesco Egro

    lead OTHER

Principal Investigators

  • Francesco M Egro, MD, MSc, MRCS · Department of Plastic Surgery, University of Pittsburgh Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-01
Primary Completion
2026-02-02
Completion
2026-02-03
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06681194 on ClinicalTrials.gov