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Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias

NCT06661278 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2025-05-31

No results posted yet for this study

Summary

The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia.

The main question it aims to answer is: Does maximum heart rate during controlled exercise tolerance testing accurately reflect maximum heart rate and peak exercise levels during free living daily physical activity in children and adolescents diagnosed with an inherited arrhythmia?

Participants will:

* Complete routine exercise tolerance testing
* Record daily physical activity and exercise over two weeks, while wearing an activity and heart rate monitor and digit diary.
* Complete a physical activity questionnaire at the end of two weeks.

Conditions

  • Long QT Syndrome
  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
  • Catecholaminergic Polymorphic Ventricular Tachycardia Type 2

Interventions

DIAGNOSTIC_TEST

Exercise tolerance test

Clinical routine exercise tolerance test using an exercise treadmill, according to the arrhythmia protocol (15 minute protocol utilising increasing speed and incline with a 6 minute recovery)

OTHER

Physical activity & heart rate monitoring

Physical activity monitoring over two weeks using Actiheart and Pro-Diary monitors to record heart rate, heart rhythm, activities engaged in and estimated intensity of activities.

Sponsors & Collaborators

  • Great Ormond Street Hospital for Children NHS Foundation Trust

    collaborator OTHER

  • Guy's and St Thomas' NHS Foundation Trust

    collaborator OTHER

  • Royal Brompton & Harefield NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Catherine E Renwick · Royal Brompton & Harefield NHS Foundation Trust

Eligibility

Min Age
6 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-18
Primary Completion
2025-11-30
Completion
2025-12-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06661278 on ClinicalTrials.gov