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Effect Supplementation of COenzyme Q10 in Acute STEMI Underwent PPCI

NCT06661018 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2024-10-28

No results posted yet for this study

Summary

Left ventricular remodeling can still occur after primary percutaneous coronary intervention (PCI). Global longitudinal strain (GLS) assessment has been used as a predictor of left ventricular remodeling. Coenzyme Q10 is known for its anti-inflammatory and antioxidant properties, which may help reduce cardiac remodeling. This study aims to determine the effect of CoQ10 administration after myocardial infarction as an adjunct to standard therapy on left ventricular remodeling, assessed through changes in GLS values.

Researchers will compare Coenzyme Q10 to a placebo to see if Coenzyme Q10 has a greater effect on improving left ventricular GLS values in patients with ST-Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention.

Conditions

  • ST Segment Elevation Myocardial Infarction (STEMI)
  • Coenzyme Q10

Interventions

DRUG

Coenzyme Q 10

participant will receive STEMI standard treatment plus oral Coenzyme Q10 (chewable tablet) 100 mg / 12 hours for 8 weeks

DRUG

Placebo

participant will receive STEMI standard treatment plus placebo /12 hours for 8 weeks

Sponsors & Collaborators

  • Universitas Diponegoro

    lead OTHER

Principal Investigators

  • Ilham Uddin, Medical Doctor, cardiologist · University of Diponegoro

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-28
Primary Completion
2024-04-30
Completion
2024-06-30

Countries

  • Indonesia

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06661018 on ClinicalTrials.gov