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Effect of Statin Treatment on Insulin Sensitivity During Myocardial Infarction

NCT01205347 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 27

Last updated 2013-09-10

No results posted yet for this study

Summary

Stress hyperglycemia during myocardial infarction (MI) is related to mortality at short and long term. Recent studies, however, revealed that chronic statin treatment may decrease both insulin sensitivity and secretion immediately after statin therapy initiation. This study aim was to investigate the dose-dependent effect of statins on insulin sensitivity in patients in the acute phase of MI.

Conditions

Interventions

DRUG

Simvastatin 80mg

Simvastatin 80mg once a day

DRUG

Simvastatin 10mg

Simvastatin 10mg once a day

Sponsors & Collaborators

  • Brasilia Heart Study Group

    lead OTHER

Principal Investigators

  • Andrei C Sposito, MD PhD · Faculty of Medical Sciences, State University of Campinas

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-10-31
Primary Completion
2013-09-30
Completion
2013-09-30

Countries

  • Brazil

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01205347 on ClinicalTrials.gov