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Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia

NCT06633406 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 192

Last updated 2026-01-09

No results posted yet for this study

Summary

Every year in the European Union, thousands of babies are exposed to anaesthesia before they are born because their mothers need surgery during pregnancy. While these surgeries are necessary, there is a concern that the anaesthesia might affect the baby's brain development. However, there isn't enough research to know for sure how this exposure might impact the child's intelligence or behavior later in life.

The goal of this cohort study is to compare the intelligence and neurodevelopmental outcome of children prenatally exposed to general anaesthesia for maternal abdominal surgery with those of unexposed children and with those of children prenatally exposed to maternal inflammation.

Conditions

  • General Anaesthesia During Pregnancy

Interventions

OTHER

Age-appropriate Wechsler Intelligence Test

2.5-6 years: Wechsler Preschool and Primary Scale of Intelligence for children (WPPSI IV) 7-16 years: Wechsler Intelligence Scale for Children (WISC V) \>17 years: Wechsler Adult Intelligence Scale (WAIS IV)

OTHER

Disruptive Behavior Disorders Rating Scale

Dutch version of the Disruptive Behavior Disorders Rating Scale

OTHER

Social Responsiveness Scale

3-18 years: social responsiveness scale 2 (SRS-2) \>19 years: Social Responsiveness Scale - Adult version (SRS-A)

Sponsors & Collaborators

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Sarah Devroe, MD, Phd · UZ Leuven

Eligibility

Min Age
2 Years
Max Age
27 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-14
Primary Completion
2027-10-31
Completion
2027-12-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06633406 on ClinicalTrials.gov