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Fertility and Ovarian Reserve in Female Childhood Cancer Survivors

NCT06626282 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 340

Last updated 2024-11-01

No results posted yet for this study

Summary

Ovarian function impairment affects the quality of life of the survivors of paediatric cancer by impacting fertility, bone quality and mental and cognitive health. The objective of this project is to evaluate the impact of low-intermediate dose alkylating agents associated or not with ovarian cryopreservation technique on ovarian function in female survivors of paediatric cancer. We propose to identify new epigenetic markers in order to predict the risk of premature ovarian insufficiency. The project will be led by a national multi-disciplinary team (paediatric oncologists, gynaecologists, endocrinologists). Paediatric cancer clinical data (therapy, fertility preservation, ...) will be extracted from the Paediatrics Late Effects database and additional data will be collected during PRINCESS fertility evaluation. Through translational and multi-disciplinary approaches, results should improve quality of life and fertility preservation in female survivors of paediatric cancer by developing new personalised screening tools for premature ovarian insufficiency.

Conditions

  • Childhood Cancer Survivors
  • Fertility
  • Ovarian Reserve
  • CED
  • Ovarian Reserve Markers
  • Cryopreservation
  • Alkylating Agents
  • Female

Sponsors & Collaborators

  • La Fondation contre le cancer, Belgique

    collaborator UNKNOWN

  • Centre Hospitalier Universitaire de Liege

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-10-09
Primary Completion
2026-12-31
Completion
2028-12-31

Countries

  • Belgium

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06626282 on ClinicalTrials.gov