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The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects

NCT06625528 · Status: ACTIVE_NOT_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2024-10-15

No results posted yet for this study

Summary

The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through:

1. Primary outcomes:

* The clinical parameters including: Probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain.
* The radiographic parameters including: Marginal bone level (MBL), bone-defect fill.
2. Secondary outcome: The level of BMP-2 in Gingival crevicular fluid (GCF).

Conditions

  • Treatment of Periodontal Intra-bony Defects

Interventions

BIOLOGICAL

open flap debridement

does lyophilized platelet rich fibrin combined with open flap debridement or combination of open flap debridement, lyophilized platelet rich fibrin and nano-crystalline hydroxyapatite bone substitute can add benefits to open flap debridement alone or not

Sponsors & Collaborators

  • Al-Azhar University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-19
Primary Completion
2025-05-31
Completion
2025-05-31

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06625528 on ClinicalTrials.gov