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Treatment of Intrabony Defects With L-PRF Membrane With or Without Collagen Membranes

NCT05496608 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 63

Last updated 2022-08-25

No results posted yet for this study

Summary

For patients having periodontal intrabony lesions, three treatment modalities were executed to evaluate the effect of protecting Leukocyte rich -Platelet Rich Fibrin harvests (applied in the bony defects) with resorbable collagen membranes. Clinical Outcomes recorded were the Plaque index (PI), Gingival index (GI), probing depth reduction (PD), Clinical attachment level (CAL), and radiographic defect depth changes.

For the biochemical evaluation: levels of PDGF-BB and VEGF obtained from crevicular fluid by Perio-Paper strips were assessed using ELIZA.

Conditions

  • Periodontal Bone Loss
  • Periodontal Diseases

Interventions

PROCEDURE

L-PRF

a blood sample is obtained from the patient, and centrifuged to prepare a leukocyte platelet rich fibrin harvest that is applied within the derided lesion.

PROCEDURE

OFD

Full thickness flap elevation to gain access to the infrabony lesion for debridement followed by flap closure.

PROCEDURE

CM

Xenogeneic collagen membranes that are used as barrier membranes in guided tissue regeneration of periodontal defects

Sponsors & Collaborators

  • Future University in Egypt

    lead OTHER

Principal Investigators

  • Ahmed Gamal, P.H.D · Professor of periodontology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2021-11-30
Completion
2022-02-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05496608 on ClinicalTrials.gov