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Predictive Modeling of Necrotizing Skin Infections in Snakebite Patients

NCT06622343 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 99

Last updated 2024-10-02

No results posted yet for this study

Summary

This multicenter retrospective study aims to identify the risk factors associated with necrotizing skin infections following venomous snakebites and to develop a predictive model. Clinical data from 99 patients treated between January 2020 and April 2024 at three hospitals in Guangdong Province, China, were analyzed.

Conditions

  • Necrotizing Skin Infections
  • Snakebite Envenomation

Interventions

DRUG

Antivenom Serum

Intravenous administration of 6000 IU of antivenom serum was given to patients envenomed by pit vipers. This treatment was based on Chinese guidelines for the management of snakebites. Additionally, patients received supportive treatments, including antibiotics to prevent infection, antihistamines for allergic reactions, and magnesium sulfate for localized swelling and pain relief.

PROCEDURE

Wound Debridement

Patients who did not develop necrotizing skin infections received wound management, including multiple punctures using a three-edged needle for toxin drainage, along with standard wound care and debridement as necessary to prevent infection and promote healing.

Sponsors & Collaborators

  • Central People's Hospital of Zhanjiang

    collaborator OTHER

  • Affiliated Hospital of Guangdong Medical University

    collaborator OTHER

  • Guangzhou Institute of Respiratory Disease

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-01
Primary Completion
2024-04-01
Completion
2024-04-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06622343 on ClinicalTrials.gov