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The Effect of Aerobic and Anaerobic Exercise on Oxidative Stress and Cellular Fitness in Healthy Trained Young Men

NCT06582862 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2024-09-03

No results posted yet for this study

Summary

This study aims to analyze the effects of aerobic and anaerobic exercise on health at the molecular level. By examining these effects, the study seeks to provide the public with insights into which types of exercise offer the most significant health benefits. Participants will engage in aerobic and anaerobic exercises for one month, with 5 mL of venous blood collected by experienced phlebotomists both before and after the exercise period. While blood collection may cause mild discomfort and temporary bruising, these symptoms should subside within a few days. The collected blood will be processed to separate plasma and leukocytes for the assessment of oxidative damage, lipid profile and cellular fitness parameters. The oxidative damage markers to be measured include malondialdehyde (MDA) levels, H2O2, and antioxidants such as total antioxidant capacity, superoxide dismutase, and glutathione peroxidase. Cellular fitness will be evaluated by measuring mitochondrial biogenesis markers (succinate dehydrogenase and PGC-1A), ATP levels, and ATPase inhibitor levels. The benefits for the participants, they will receive include a laboratory assessment to evaluate cell damage, lipid profiles, and mitochondrial function. Additionally, the study results will help identify the most beneficial type of physical exercise for optimal health.

Conditions

  • Health, Subjective

Interventions

OTHER

Exercise

Subjects will do aerobic and anaerobic exercise

Sponsors & Collaborators

  • Indonesia University

    lead OTHER

Principal Investigators

  • Novi Hardiany · Fakultas Kedokteran Universitas Indonesia

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
23 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-06-01
Primary Completion
2024-09-30
Completion
2024-11-30

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06582862 on ClinicalTrials.gov