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Defining Outcome Measures for Behavioural and Emotional Problems in Dystrophinopathies

NCT06581887 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-09-03

No results posted yet for this study

Summary

Study aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task.To better understand how Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) impacts mental health and how to assess it. Participants invited to complete questionnaires about behaviour, cognitive function and social interactions, complete computer tasks and have an optional MRI brain scan,

Conditions

Interventions

BEHAVIORAL

Classical conditioning task

To evaluate the neurophysiological and physiological response to a classical conditioning task, which is comparable to findings that have been made in the mdx dystrophic mouse (deficient in Dp427). The investigators will assess correlations between the specific DMD/BMD genotype and susceptibility to conditioning, as well as the relationship between conditioning and behavioural/emotional characteristics of the syndrome.

Sponsors & Collaborators

  • Sarepta Therapeutics, Inc.

    collaborator INDUSTRY

  • University College, London

    lead OTHER

Principal Investigators

  • Francesco Muntoni, Professor · University College, London

Eligibility

Min Age
7 Years
Max Age
17 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-13
Primary Completion
2024-11-19
Completion
2024-12-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06581887 on ClinicalTrials.gov