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Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma

NCT06563362 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-11-18

No results posted yet for this study

Summary

Multicentric prospective model-based de-escalation of the elective clinical target volumes (CTV) in radiotherapy of oropharyngeal carcinoma of all stages with the goal to reduce toxicity.

The study investigates the feasibility of this approach as measured by the number of expected out-of-field recurrencies based on the individual patient's state of disease progression and risk factors

Conditions

  • Oropharynx Cancer

Interventions

RADIATION

De-escalation of irradiated volume

De-escalation of elective clinical target volumes as recommended by a model-based approach

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    collaborator OTHER

  • University Hospital, Geneva

    collaborator OTHER

  • Ospedale Regionale Bellinzona e Valli

    collaborator OTHER

  • Réseau Hospitalier Neuchâtelois

    collaborator OTHER

  • Kantonsspital Aarau

    collaborator OTHER

  • University of Zurich

    lead OTHER

Principal Investigators

  • Panagiotis Balermpas, MD · University of Zurich

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-04
Primary Completion
2029-02-28
Completion
2030-02-28

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06563362 on ClinicalTrials.gov