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Primary Radiotherapy Versus Primary Surgery for HPV-Associated Oropharyngeal Cancer

NCT03210103 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 61

Last updated 2026-01-28

No results posted yet for this study

Summary

The goal of this randomized treatment de-escalation study is to formally compare outcomes in HPV related oropharyngeal cancer tumors treated with a primary radiotherapy versus a primary surgical approach, to provide a high level of evidence to guide the selection of treatment options for a subsequent phase III trial

Conditions

  • Oropharyngeal Cancer

Interventions

RADIATION

Radiation

Standard of Care: Radiation +/- Chemotherapy

PROCEDURE

Transoral Surgery (TOS) + Neck Dissection

Transoral Surgery (TOS) + Neck Dissection (plus radiation, if required)

Sponsors & Collaborators

  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    lead OTHER

Principal Investigators

  • David Palma · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-26
Primary Completion
2028-08-15
Completion
2028-08-15

Countries

  • Australia
  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03210103 on ClinicalTrials.gov