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Temporal Memory in Schizophrenic Patients

NCT06562504 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2024-08-20

No results posted yet for this study

Summary

Temporal order memory deficits are a central feature of cognitive abnormalities in schizophrenia. The dorsolateral prefrontal cortex contributes to the extraction of temporal contextual information. Transcranial direct current stimulation (tDCS) and interim testing have been shown to be external techniques that can improve temporal order memory deficits in schizophrenia patients. Transcranial alternating current stimulation (tACS) can also improve cognitive functioning in patients with schizophrenia. This study intends to investigate the learning effects of temporal order memory under two learning strategies during tDCS targeting the left dorsolateral prefrontal cortex (L-DLPFC) and transcranial direct current stimulation (tDCS) interventions in patients with schizophrenia, to investigate whether it can promote the retention of temporal order memory in patients, and to compare the differences in the effects of the two intervention modalities.

This study was planned to recruit 75 patients diagnosed with schizophrenia from the hospital.

A single online tDCS (2 mA × 20 min) and tACS (1.5 mA × 20 min, theta rhythm) intervention was conducted during which participants performed a temporal-sequence memory task for visual pictures, and test scores were compared for each stimulus type on an intermediate test and repetition of the two strategies of learning.

Conditions

  • Patients With Schizophrenia

Interventions

DEVICE

Transcranial direct current stimulation (tDCS)- anodal group

2mA/20mins/session;

DEVICE

Transcranial direct current stimulation (tDCS)- sham group

0mA/20mins/session

DEVICE

transcranial alternating current stimulation (tACS)-tACS group

1.5 mA/20 min/session; 6HZ, theta

Sponsors & Collaborators

  • Xiaofeng Ma

    lead OTHER

Principal Investigators

  • Xiaofeng Ma, Professor · Northwest Normal University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-15
Primary Completion
2024-09-30
Completion
2024-09-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06562504 on ClinicalTrials.gov