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Effects of tDCS Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia

NCT06538259 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2024-08-05

No results posted yet for this study

Summary

The semantic processing deficit stands as a central feature of cognitive abnormalities in schizophrenia. Both transcranial direct current stimulation (tDCS) and retrieval practice have been demonstrated as external techniques capable of ameliorating the semantic processing deficit in individuals with schizophrenia. The inquiry examines whether the combined effect of tDCS and retrieval practice, following tDCS intervention targeting the left dorsolateral prefrontal cortex (L-DLPFC) in patients with schizophrenia, contributes to the preservation of semantic memory in these individuals.

Investigators recruited 52 patients diagnosed with schizophrenia from hospitals. After five consecutive days of tDCS intervention (2 mA × 20 mins, twice per day), Investigators administered a word list memorization task comparing retrieval practice and restudy strategies. Subsequently, Investigators observed their immediate and delayed memory performance through tests.

Conditions

  • Schizophrenic Patients

Interventions

DEVICE

Transcranial direct current stimulation (tDCS)-anodal group

2mA/20mins/session; 2sessions/day,5days

DEVICE

Transcranial direct current stimulation (tDCS)-sham group

0mA/20mins/session; 2sessions/day,5days

Sponsors & Collaborators

  • Northeast Normal University

    lead OTHER

Principal Investigators

  • Xiaofeng Ma, Professor · Northwest Normal University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-24
Primary Completion
2024-01-30
Completion
2024-04-15

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06538259 on ClinicalTrials.gov