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National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry

NCT06546137 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1211

Last updated 2026-05-08

No results posted yet for this study

Summary

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are:

Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.

Conditions

  • Cardiomyopathy, Hypertrophic
  • Cardiomyopathy, Dilated
  • Cardiomyopathy Restrictive
  • Arrhythmogenic Right Ventricular Dysplasia
  • Non-Compaction Cardiomyopathy
  • Familial Hypercholesterolemia
  • Marfan Syndrome
  • Ehlers-Danlos Syndrome, Vascular Type
  • Loeys-Dietz Syndrome
  • Long QT Syndrome
  • Short Qt Syndrome
  • Brugada Syndrome
  • Catecholaminergic Polymorphic Ventricular Tachycardia
  • Sudden Cardiac Death

Interventions

DIAGNOSTIC_TEST

whole genome sequencing

whole genome sequencing of genomic DNA extracted from buccal swab

Sponsors & Collaborators

  • Instituto Nacional de Cardiologia de Laranjeiras

    collaborator OTHER

  • Universidade Federal do Rio de Janeiro

    collaborator OTHER

  • Hospital do Coracao

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-30
Primary Completion
2026-08-31
Completion
2026-08-31

Countries

  • Brazil

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06546137 on ClinicalTrials.gov