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Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis

NCT06545786 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 265

Last updated 2025-04-08

No results posted yet for this study

Summary

Postoperative neurocognitive disorders (PND) are serious and common complications after surgery, especially in elderly patients. These disorders can affect cognitive functions for years, deteriorating quality of life and increasing hospital stays and medical costs. Diagnosing PND is challenging due to their varied manifestations, such as memory and attention problems, and the lack of standardized criteria and biomarkers.

One well-studied form of PND is postoperative delirium (POD). According to the ICD-10, POD is an organic cerebral syndrome characterized by disturbances in consciousness, attention, perception, and other cognitive functions. Researchers suggest that POD development involves a combination of predisposing and precipitating factors.

Electroencephalography (EEG) has been used in anesthesiology to assess anesthesia depth and intraoperative awareness. Modern EEG analysis methods, like spectral analysis, offer new ways to evaluate patients' neurophysiological states. Studies show that EEG monitoring can predict complications such as intraoperative stroke and delirium, particularly in cardiothoracic and neurosurgical operations.

The relationship between EEG patterns and POD is not well understood. Specific EEG patterns may indicate the risk of POD, aiding in the identification of risk factors and prevention methods. This could help anesthesiologists and surgeons optimize their approaches, reducing the risk of cognitive complications.

Conditions

  • Surgery
  • Postoperative Delirium
  • Anesthesia
  • Silent Stroke
  • Emergence Delirium

Interventions

DEVICE

Intraoperative electroencephalography

EEG recording will be performed using the standard 16-electrode configuration according to the international "10-20" system. During the recording, electrode impedances will be maintained at a level not exceeding 5 kilo-ohms.

Sponsors & Collaborators

  • Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology

    lead OTHER

Principal Investigators

  • Valery Likhvantsev, PhD · Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-25
Primary Completion
2027-08-20
Completion
2027-08-20

Countries

  • Russia

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06545786 on ClinicalTrials.gov