Registry of Endovascular Treatment for Vertebrobasilar Dissecting Aneurysms in China

Summary

The incidence of vertebrobasilar dissecting aneurysms (VBDAs) is about 1/100,000\~1.5/100,000, and it is one of the most important causes of stroke in young and middle-aged people. In recent years, with the development of medical imaging technology, the detection rate of this disease has been increasing year by year. The natural prognosis of VBDAs is complex and varied, with uncertainty: (1) it may have a benign course, and the imaging follow-up may show that the diseased vessels are repaired and improved or remain stable for a long period of time; (2) it may present with ischemic stroke caused by hemodynamic alteration or thromboembolism, which may result in severe neurological impairment; (3) it may occur as a result of rupture of aneurysms leading to subarachnoid hemorrhage, endangering the patient's life; (4) progressive enlargement of VBDAs causing occupying effects, which may be manifested as headache in mild cases, or hemiplegia of limbs and choking on drinking water in severe cases. Up to now, there is a lack of objective and uniform diagnostic and therapeutic guidelines for the natural regression of VBDAs and the benefits of surgery, and the treatment is mostly empirical, which makes it difficult to accurately determine the clinical prognosis of VBDAs and formulate appropriate treatment strategies.

Therefore, against the above background, we designed the present study. This study was a multicenter, prospective, registry study. We enrolled patients with unruptured VBDAs who met the inclusion and exclusion criteria, and a multi-disciplinary team formulated the treatment modalities for the patients, which were categorized into the conservative observation group, the stent-assisted coiling group, and the flow diverter group. The aim of our study was to investigate the effects of different treatment modalities on the prognosis of patients with VBDAs, as well as to stratify the risk factors of the patients, to explore the individualized treatment modalities of the patients, and to improve the diagnosis and treatment of this clinically refractory cerebrovascular disease.

Conditions

• Dissecting Aneurysm of Cerebral Artery

Interventions

OTHER

Multi-disciplinary assessment

1. Comprehensive evaluation was performed by multi-disciplinary experts to assess the prognosis of unruptured VBDAs and develop appropriate treatment strategies. 2. Preoperative cranial MRI, CTA, DSA and other imaging tests were used to determine the aneurysm site, morphology, size, presence of compression symptoms, and whether it was accompanied by an intramural hematoma.

Sponsors & Collaborators

• Beijing Chao Yang Hospital

  collaborator OTHER

• Peking University International Hospital

  collaborator OTHER

• The First People's Hospital of Lianyungang

  collaborator OTHER

• Chinese PLA General Hospital

  collaborator OTHER

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

  collaborator OTHER

• Yichang Central People's Hospital

  collaborator OTHER

• Taihe Hospital

  collaborator OTHER

• Liaocheng People's Hospital

  collaborator OTHER

• Binzhou People's Hospital

  collaborator OTHER

• The First Affiliated Hospital of Shanxi Medical University

  collaborator OTHER

• Beijing Aerospace General Hospital

  collaborator OTHER

• The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• Dalian Municipal Central Hospital

  collaborator OTHER

• Shijiazhuang Third Hospital

  collaborator UNKNOWN

• Affiliated Hospital of Chengde Medical University

  collaborator OTHER

• Xingtai People's Hospital

  collaborator OTHER

• Taian City Central Hospital

  collaborator OTHER

• Wuhan Brain Hospital

  collaborator UNKNOWN

• Beijing Tiantan Hospital

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-01-01

Primary Completion

2031-01-01

Completion

2032-01-01

Countries

• China

Study Locations