Evaluation of the Pharmacokinetic Drug-drug Interactions Between VX-993 and Metformin in Healthy Adults
NCT06523595 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 31
Last updated 2025-01-31
Summary
The purpose of this study is to evaluate the pharmacokinetic drug-drug interactions, safety, and tolerability of co-administration of VX-993 and metformin in healthy participants.
Conditions
Interventions
- DRUG
-
VX-993
Suspension for Oral Administration.
- DRUG
-
Tablets for Oral Administration.
Sponsors & Collaborators
-
Vertex Pharmaceuticals Incorporated
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Max Age
- 55 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2024-07-31
- Primary Completion
- 2024-12-31
- Completion
- 2024-12-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)
NCT07121959 ·Status: COMPLETED ·Phase: PHASE1
-
Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions
NCT03335423 ·Status: COMPLETED ·Phase: PHASE1
-
Drug Interactions From Simultaneous Administration Of Metformin And GSK189075 To Subjects With Type 2 Diabetes
NCT00376038 ·Status: COMPLETED ·Phase: PHASE1
-
Drug Interaction Study of Levoketoconazole and Metformin
NCT03880825 ·Status: COMPLETED ·Phase: PHASE1
-
A Comparison of SLx-4090 in Combination With Metformin Versus Metformin Therapy Alone in Patients With Type 2 Diabetes
NCT00871936 ·Status: COMPLETED ·Phase: PHASE2
-
Relative Bioavailability of 2 Fixed Dose Combinations of Empagliflozin/Metformin Extended Release (XR) Compared With Single Tablets
NCT02106923 ·Status: COMPLETED ·Phase: PHASE1
-
The Drug-drug Interaction of SHR3824 and Metformin
NCT02354027 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-Drug Interaction Study of Mitiglinide and Gemfibrozil
NCT00566865 ·Status: COMPLETED ·Phase: PHASE1
-
4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes
NCT03538743 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Explore Pharmacokinetic Interaction Between Rilpivirine and Metformin in Healthy Participants
NCT01719614 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of SHR3824 in Combination With Metformin in Subjects With Type 2 Diabetes
NCT04390295 ·Status: UNKNOWN ·Phase: PHASE3
-
Clinical Trial to Investigate the Pharmacokinetic/Pharmacodynamic Drug-Drug Interaction of Pyrimethamine and Metformin IR
NCT01973933 ·Status: COMPLETED ·Phase: PHASE1
-
Drug-Drug Interaction Study to Evaluate the Effect of PF-06865571 on Metformin Pharmacokinetics
NCT03593707 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Compare MP-513 20mg & Metformin XR 1000mg FDC With Coadministration of the Two Separate Drugs
NCT03787017 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Assess the Effect of Plazomicin on the Pharmacokinetics of Metformin
NCT03270553 ·Status: COMPLETED ·Phase: PHASE1
-
A Relative Bioavailability Study of Metformin HCL Tablets, 1000 mg Under Fasting Conditions
NCT00865033 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Investigate Whether Pharmacokinetic and Pharmacodynamic Interactions Exist Between Metformin and Canagliflozin (JNJ-28431754) in Healthy Volunteers
NCT01756417 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of SCH 497079 on Metabolic Parameters and Influence of Race/Ethnic Origin on Therapeutic Response (Study P05338)(COMPLETED)
NCT00673465 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of the Effect of RG1662 on Metformin in Healthy Volunteers
NCT02342925 ·Status: COMPLETED ·Phase: PHASE1
-
Metformin Extended Release Versus Metformin Immediate Release in Subjects With Type 2 Diabetes
NCT02252965 ·Status: COMPLETED ·Phase: PHASE4
-
Study to Evaluate the Drug-drug Interactions Between Metformin and AMG 510 in Healthy Participants
NCT05550129 ·Status: COMPLETED ·Phase: PHASE1
-
Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine
NCT06071442 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics of Metformin Intolerance
NCT03361878 ·Status: COMPLETED ·Phase: PHASE4
-
Assessing the Efficacy, Safety, and Tolerability of Met DR in Subjects With T2DM Over 12 Weeks
NCT01819272 ·Status: COMPLETED ·Phase: PHASE2
-
The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus
NCT00463502 ·Status: COMPLETED ·Phase: PHASE4